Adipose is used in regenerative medicine procedures because mesenchymal stem cells can be isolated from almost every tissue in the human body. The central connecting aspect to explain this fact is that all of these tissues are vascularized and that every blood vessel in the body has mesenchymal cells in abluminal locations. These perivascular cells can be summarily called Pericytes. Adipose-Derived MSCs are being used therapeutically because they undergo homing to sites of inflammation or tissue injury and they secrete massive levels of bioactive agents that are both immunomodulatory and trophic.
Did you know?
MSCs are found as perivascular cells and, even in large vessels ,in the adventitia but, again, not in the generic connective tissue. To best understand the native, functional properties of MSCs, think PERICYTES.
Why is adipose used?
Adipose is recognized to possess the greatest microvascular organ in the body. Many scientific papers suggest that adipose-derived (AD) stem/stromal cells of mesodermal origin provide between 1000 and 2500 times the actual numbers found in bone marrow. With the easy collection of adipose tissue, less penetration, widely heterogeneous cellular populations, and important immune-privileged properties, subdermal fat deposits serve as a primary source for gathering stem/stromal cells.
What are some of the roles Adipose tissue serves?
The small adipose cells are found to be closely associated with the vascular tissues of our bodies. We recognize these cells as serving important roles in maintaining normal tissue content (homeostasis) plus having the ability to respond to injury or disease processes in a constant effort to heal or repair damaged cells.
How long does the process/procedure take?
The procedure takes up to 1 hour.
How do you obtain it?
Adipose is readily available and safely accessible from the subdermal fat deposits found in the abdomen and thigh areas. These are gently removed via closed syringe lipoaspiration and then compressed by centrifugation.
Do's & Don'ts
Pre and Post injection protocols should be discussed with your doctor. However, having a healthy diet, being well hydrated, and active will help your recovery. Patients are generally able to resume normal activities within a few days.
What is the evidence Adipose plays in the healing process?
Clinical trials are gradually being released, many requiring several years to acquire data, compile, and report. A vast majority of such reports are providing clear clinical evidence of patient safety and effective clinical treatment outcomes.
What is the long-term outcome?
There are an estimated 150,000 human clinical uses and therapies in MSK applications. All with a remarkable efficacy and safety profile.
What can I expect immediately following the procedure?
Immediately following an adipose procedure, your site of injection will probably be more sore than the harvesting location. The local anesthesia used wears off and pain relief medicine may be prescribed or recommended.